|
|
|
ProgramSessions schedule and confirmed speakers May 22nd 12:00-13:15 : Registration 13:15-13:30 : Introduction by the local organizers 13:30 - 15:30 : Inflammation Chairs : Klaudia Brix, Gilles Lalmanach - Nathalie Vergnolle, IRSD, Université de Toulouse III, INSERM, INRAE, ENVT, Toulouse, France: “ Thrombin stories in gut inflammation” - Paulina Kasperkiewicz, University of Science and Technology, Wrocław, Poland: “Targeting proteases in inflammation with chemical tools”
- Fabien Lecaille, INSERM and Université Tours, France : “Binding of heparan sulfate to human cystatin C modulates inhibition of cathepsin L: putative consequences in mucopolysaccharidosis” - Su Bim Kim, Seoul National University, Korea: “The Cys/N-degron pathway mediates inflammation via oxidative stress-induced secretory autophagy” - Evegeniya Petrova, INSERM and Université Paris Cité, France: “Skin barrier defect and inflammation in Netherton syndrome: lessons from a comparative study of patients and mouse models”
15:30 - 16:00 : Coffee break
16:00 - 18:00 : Cancer Chairs: Roberta Burden, Thomas Reinheckel - Ruth Geiss-Friedlander, Institut für Molekulare Medizin und Zellforschung, Freiburg, Germany: “Dipeptidyl peptidase 9 (DPP9) and repair of DNA double-strand breaks” - Emmanuelle Liaudet-Coopman, INSERM and Institut de Recherche en Cancérologie de Montpellier, France: “Immunotherapy of triple-negative breast cancers with cathepsin D targeting antibodies”
- Paolo Cascio, University of Turin, Italy: “Role of PA28γ in promoting the degradation of unfolded proteins by the 20S proteasome” - Ana Mitrovic, Jožef Stefan Institute, Ljubljana, Slovenia: “Identification of new cathepsin V inhibitors as potential antitumor agents” - Su Ran Mun, Seoul National University, Korea: “Targeted degradation of RAS using chemical platform, AUTOTAC”
18:00 - 19:30 : Flash talks / Poster Session (1) 19:30 : Wine & Cheese
May 23th 9:30 - 11:50 : Autophagy Chairs : Lydie Combaret, Robin Ketteler - Sharon A. Tooze, The Francis Crick Institute, London, United Kingdom: “Molecular mechanisms of autophagy” - Tassula Proikas-Cezanne, Max Planck Institute for Developmental Biology and Eberhard Karls University Tübingen, Tübingen, Germany: “The role of WIPI beta propellers in autophagy and neurodegeneration”
- Robin Ketteler, University College, London, United Kingdom and Medical School Berlin, Germany: “Design and Validation of AutophagyTargeting Chimera” - Pierre Genin, Faculté de Médecine Sorbonne Université, Paris, France: “Novel mitophagy signaling pathway involving the autophagy receptor Optineurin” - Hye Yeon Kim, Seoul National University, Korea: “The Cys/N-degron pathway mediates muscle actin proteolysis” - Marlena Pozoga, Heidelberg University, Germany: “Investigating the contribution of autophagy to NatA-mediated proteostasis in Arabidopsis thaliana”
11:50 - 13:00 : Flash talks / Poster Session (2) 13:00 - 14:00 : Lunch
14:00 - 16:20 : Omics and drug design Chairs: Nik Subramanian, Chahrazade El Amri, Oliver Schilling - Xavier Nissan, ISTEM, Evry, France: “Drug repurposing for LGMD: An innovative approach combining pluripotent stem cells, phenotypical drug screening and AI-based target identification” - Yong Tae Kwon, Seoul National University, Korea: “The AUTOTAC chemical biology platform in drug development for targeted degradation via the autophagy-lysosome system”
- Ami Navon, The Weizmann Institute of Science, Rehovot, Israel:“An inherent oxidative switch regulates proteasome reprograming” - Karen Plé, CNRS and Université d’Orléans, France:“PROteolysis TArgeting Chimeras (PROTACs): developing Estrogen Receptor PROTACS for the detection of endocrine disruptors” - Oded Kleifeld, Technion-Israel Institute of Technology, Haifa, Israel:“Activity-guided proteomic profiling of proteasomes uncovers a variety of active (and inactive) proteasome species” - Gunnar Dittmar, Luxembourg Institute of Health, Strassen, Luxembourg: “Peptide-based interactomics of the claudin family identifies a linear motif that recruits the proteasome to the Tight-junctions”
16:20 - 16h50 : Coffee break
16:50 - 18:50 : Host-Pathogens interactions Chairs : Beatriz Orosa, Carmela Giglione - Steven Spoel, University of Edinburgh, United Kingdom: “Ubiquitin ligase relays and diverse chain topologies coordinate immune signalling” - Suayb Üstün, Ruhr-University of Bochum, Germany: “How plant pathogens manipulate protein degradation pathways”
- Thierry Meinnel, Université Paris-Saclay, CEA, CNRS, Gif-sur-Yvette, France: “How the IpaJ virulence factor alters cellular proteostasis in the course of Shigella flexneri infection” - Beatriz Orosa, University of Edinburgh, United Kingdom: “Improving crop immunity by exploitation of the ubiquitin system” - Daniel Vogele, University Medical Center Freiburg, Germany: “Substrate selectivity of Sars-Cov-2 papain-like protease PLPro”
19:00 : Cocktail
May 24th 9:30 - 11:50 : Aging & Neurodegenerative Diseases Chairs : Niki Chondrogianni, Bertrand Friguet - Niki Chondrogianni, National Hellenic Research Foundation, Athens, Greece: “20S proteasome activation in the battle against ageing and Alzheimer's disease” - Chahrazade El Amri, Sorbonne Université, CNRS, Inserm, B2A-IBPS, Paris, France : “Pharmacological modulators of kallikrein-related peptidases: design, characterization and therapeutic applications in neurodegeneration”
- Marie-Odile Fauvarque, CEA, Inserm, Université Grenoble Alpes, France: “Identification of chemicals and mutations breaking the USP8 interaction with its endocytic substrate CHMP1B” - Jihoon Lee, Seoul National University, Korea: “Targeted degradation of α-synuclein aggregates via the AUTOTAC technology” - Nicoleta Moisoi, De Montfort University, Leicester, United Kingdom: “Mitochondria-nucleus communication. A role for mitochondrial quality control and DNA damage signaling in neurodegeneration” - Daniel Youngjae Park, Seoul National University, Korea:“Targeted Protein Degradation as a novel therapeutic approach against Amyotrophic Lateral Sclerosis (ALS)”
11:50 - 12:30: SFBBM best poster/presentation prize + WG1 ProteoCure meeting conclusions |
