Program

Sessions schedule and confirmed speakers

May 22^nd

12:00-13:15 : Registration

13:15-13:30 : Introduction by the local organizers

13:30 - 15:30 : Inflammation 

Chairs : Klaudia Brix, Gilles Lalmanach

- Nathalie Vergnolle, IRSD, Université de Toulouse III, INSERM, INRAE, ENVT, Toulouse, France: “ Thrombin stories in gut inflammation”

- Paulina Kasperkiewicz, University of Science and Technology, Wrocław, Poland: “Targeting proteases in inflammation with chemical tools”

- Fabien Lecaille, INSERM and Université Tours, France : “Binding of heparan sulfate to human cystatin C modulates inhibition of cathepsin L: putative consequences in mucopolysaccharidosis”

- Su Bim Kim, Seoul National University, Korea:  “The Cys/N-degron pathway mediates inflammation via oxidative stress-induced secretory autophagy”

- Evegeniya Petrova, INSERM and Université Paris Cité, France: “Skin barrier defect and inflammation in Netherton syndrome: lessons from a comparative study of patients and mouse models”

15:30 - 16:00 : Coffee break

16:00 - 18:00 : Cancer 

Chairs: Roberta Burden, Thomas Reinheckel 

- Ruth Geiss-Friedlander, Institut für Molekulare Medizin und Zellforschung, Freiburg, Germany: “Dipeptidyl peptidase 9 (DPP9) and repair of DNA double-strand breaks”

- Emmanuelle Liaudet-Coopman, INSERM and Institut de Recherche en Cancérologie de Montpellier, France: “Immunotherapy of triple-negative breast cancers with cathepsin D targeting antibodies”

- Paolo Cascio, University of Turin, Italy: “Role of PA28γ in promoting the degradation of unfolded proteins by the 20S proteasome”

- Ana Mitrovic, Jožef Stefan Institute, Ljubljana, Slovenia: “Identification of new cathepsin V inhibitors as potential antitumor agents”

- Su Ran Mun, Seoul National University, Korea: “Targeted degradation of RAS using chemical platform, AUTOTAC”

18:00 - 19:30 : Flash talks / Poster Session (1)

19:30 : Wine & Cheese

May 23^th

9:30 - 11:50 : Autophagy 

Chairs : Lydie Combaret, Robin Ketteler

- Sharon A. Tooze, The Francis Crick Institute, London, United Kingdom: “Molecular mechanisms of autophagy”

- Tassula Proikas-Cezanne, Max Planck Institute for Developmental Biology and Eberhard Karls University Tübingen, Tübingen, Germany: “The role of WIPI beta propellers in autophagy and neurodegeneration”

- Robin Ketteler, University College, London, United Kingdom and Medical School Berlin, Germany: “Design and Validation of AutophagyTargeting Chimera”

- Pierre Genin, Faculté de Médecine Sorbonne Université, Paris, France: “Novel mitophagy signaling pathway involving the autophagy receptor Optineurin”

- Hye Yeon Kim, Seoul National University, Korea: “The Cys/N-degron pathway mediates muscle actin proteolysis”

- Marlena Pozoga, Heidelberg University, Germany: “Investigating the contribution of autophagy to NatA-mediated proteostasis in Arabidopsis thaliana”

11:50 - 13:00 : Flash talks / Poster Session (2)

13:00 - 14:00 : Lunch 

14:00 - 16:20 : Omics and drug design

Chairs: Nik Subramanian, Chahrazade El Amri, Oliver Schilling

- Xavier Nissan, ISTEM, Evry, France: “Drug repurposing for LGMD: An innovative approach combining pluripotent stem cells, phenotypical drug screening and AI-based target identification”

- Yong Tae Kwon, Seoul National University, Korea: “The AUTOTAC chemical biology platform in drug development for targeted degradation via the autophagy-lysosome system”

- Ami Navon, The Weizmann Institute of Science, Rehovot, Israel:“An inherent oxidative switch regulates proteasome reprograming”

- Karen Plé, CNRS and Université d’Orléans, France:“PROteolysis TArgeting Chimeras (PROTACs): developing Estrogen Receptor PROTACS for the detection of endocrine disruptors”

- Oded Kleifeld, Technion-Israel Institute of Technology, Haifa, Israel:“Activity-guided proteomic profiling of proteasomes uncovers a variety of active (and inactive) proteasome species”

- Gunnar Dittmar, Luxembourg Institute of Health, Strassen, Luxembourg: “Peptide-based interactomics of the claudin family identifies a linear motif that recruits the proteasome to the Tight-junctions”

16:20 - 16h50 : Coffee break

16:50 - 18:50 : Host-Pathogens interactions

Chairs : Beatriz Orosa, Carmela Giglione

- Steven Spoel, University of Edinburgh, United Kingdom: “Ubiquitin ligase relays and diverse chain topologies coordinate immune signalling”

- Suayb Üstün, Ruhr-University of Bochum, Germany: “How plant pathogens manipulate protein degradation pathways”

- Thierry Meinnel, Université Paris-Saclay, CEA, CNRS, Gif-sur-Yvette, France: “How the IpaJ virulence factor alters cellular proteostasis in the course of Shigella flexneri infection”

- Beatriz Orosa, University of Edinburgh, United Kingdom: “Improving crop immunity by exploitation of the ubiquitin system”

- Daniel Vogele, University Medical Center Freiburg, Germany: “Substrate selectivity of Sars-Cov-2 papain-like protease PLPro”

19:00 : Cocktail

May 24^th

9:30 - 11:50 : Aging & Neurodegenerative Diseases 

Chairs : Niki Chondrogianni, Bertrand Friguet

- Niki Chondrogianni, National Hellenic Research Foundation, Athens, Greece: “20S proteasome activation in the battle against ageing and Alzheimer's disease”

- Chahrazade El Amri, Sorbonne Université, CNRS, Inserm, B2A-IBPS, Paris, France : “Pharmacological modulators of kallikrein-related peptidases: design, characterization and therapeutic applications in neurodegeneration”

- Marie-Odile Fauvarque, CEA, Inserm, Université Grenoble Alpes, France: “Identification of chemicals and mutations breaking the USP8 interaction with its endocytic substrate CHMP1B”

- Jihoon Lee, Seoul National University, Korea: “Targeted degradation of α-synuclein aggregates via the AUTOTAC technology”

- Nicoleta Moisoi, De Montfort University, Leicester, United Kingdom: “Mitochondria-nucleus communication. A role for mitochondrial quality control and DNA damage signaling in neurodegeneration”

- Daniel Youngjae Park, Seoul National University, Korea:“Targeted Protein Degradation as a novel therapeutic approach against Amyotrophic Lateral Sclerosis (ALS)”

11:50 - 12:30:

SFBBM best poster/presentation prize + WG1 ProteoCure meeting conclusions